6/18/2012

Cancer Mortality and Morbidity Patterns in the U.S. Population: An Interdisciplinary Approach (Statistics for Biology and Health) Review

Cancer Mortality and Morbidity Patterns in the U.S. Population: An Interdisciplinary Approach (Statistics for Biology and Health)
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The authors of this text are a demographer a mathematical physicist and an internal diseases MD. none are professional statisticians but they all have a good understand of mathematics and survival analysis and more importantly each has knowledge about cancer from different perspectives. The theme of the book is that conquering cancer requires an interdisciplinary approach because cancers are complicated diseases and the understanding requires stochastic models and real data. Data on cancer come from many sources. There is the laboratory experiments on cells and animals (often mice), the genetic aspects, the epidemiologic viewpoint and more. The authors know that breakthroughs are occurring on all levels but what has held things back in the compartmentalization of study disciplines and their unique jargon. This creates poor communication and makes it difficult to share results and synthesize results. But a multidisciplinary approach where everyone sheds their jargon and works together to understand what the other person is doing is the efficient way top attain success. I believe this has been proven over and over again in times of war when efficiency becomes a necessity. The Manhattan project with the scientists from various disciplines coming together at Los Alamos under the leadership of J.Robert Oppenheimer is the reason we developed the bomb ahead of Germany and Russia and in time to end the war with Japan.
This book is a compendium of hitory and methods in the fight against cancer and it provides in one source the detailed research from multiple disciplines To model and understand the various types of cancers and their similarities and differences. This is particularly exemplified in chapter 7. Each chapter has an extensive list of references. As the publisher states this book is the first of its kind to describe the interdisciplinary approach in biomedical studies. I agree with that and hope that there will be more to come like this.


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The purpose of this book is to examine the etiology of cancer in large human populations using mathematical models developed from an inter-disciplinary perspective of the population epidemiological, biodemographic, genetic and physiological basis of the mechanisms of cancer initiation and progression. In addition an investigation of how the basic mechanism of tumor initiation relates to general processes of senescence and to other major chronic diseases (e.g., heart disease and stroke) will be conducted.

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