1/25/2012

Mathematical Modeling And Simulation In Enteric Neurobiology Review

Mathematical Modeling And Simulation In Enteric Neurobiology
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This unique book fills an important need in predicting the effect of drugs on enteric motion, starting from first principles in pharmacology, neurobiology, and biophysics. A most valuable aspect is formulation of a comprehensive and sophisticated mathematical model which links drug effects on ionic channels (and currents) to produce electromagnetic waves that produce motion. After a first introductory chapter, the remaining 8 chapters isolate and predict the effect of ion channel flux, drugs, and repetitive stimulation on smooth muscle, myoelectrical activity, synaptic transmission, neuronal assemblies, multiple neurotransmission (e.g., acetylcholine and serotonin), the functional unit, and ultimately the dynamics of intestinal propulsion.
Rather than a phenomenological approach, the synthesis of the comprehensive predictive computational model introduced in this book allows understanding of complex mechanisms and modulation of enteric motion by rigorous application of biophysical and physiological knowledge. This prediction is important in understanding pathophysiology of motility disorders and drug effects.
I know of no similar compendium of such models in a compact, well organized, clearly written and well illustrated book.


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The lack of scientists equally trained and prepared to understand both mathematics and biology/medicine hampers the development and application of computer simulation methods in biology and neurogastrobiology. Currently, there are no texts for navigating the extensive and intricate field of mathematical and computational modeling in neurogastrobiology. This book bridges the gap between mathematicians, computer scientists and biologists, and thus assists in the study and analysis of complex biological phenomena that cannot be done through traditional in vivo and in vitro experimental approaches.
The book recognizes the complexity of biological phenomena under investigation and treats the subject matter with a degree of mathematical rigor. Special attention is given to computer simulations for interpolation and extrapolation of electromechanical and chemoelectrical phenomena, nonlinear self-sustained electromechanical wave activity, pharmacological effects including co-localization and co-transmission by multiple neurotransmitters, receptor polymodality, and drug interactions.
Mathematical Modeling and Simulation in Enteric Neurobiology is an interdisciplinary book and is an essential source of information for biologists and doctors who are interested in knowing about the role and advantages of numerical experimentation in their subjects, as well as for mathematicians who are interested in exploring new areas of applications.
Contents: Overview of Enteric Neurobiology; Myoelectrical Activity of the Smooth Muscle; Pharmacology of Myoelectrical Activity; Physicochemical Basis of Synaptic Transmission; Neuronal Assemblies; Multiple Neurotransmission; Functional Unit; Dynamics of Intestinal Propulsion.

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